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#Jochen dermatology skin
#Jochen dermatology plus

AEs: flu-like symptoms 5 vs 6 (483-987)īThe studies were ordered by summary findings numbers assigned in the original Cochrane review.

AEs: Mild nausea after PUVA (n=NR n), hypotension in ECP group (n=1).

Summary of key primary and secondary outcomes. Reported outcomes varied across studies, prohibiting conclusive assessments of the safety, efficacy, and HRQoL impact of these interventions. Many trials included in the review were either inadequate in methodological quality, heterogenous in design, or had insufficient sample sizes. Using GRADE (Grading of Recommendations, Assessment, Development and Evaluations) criteria, the authors report a lack of high-certainty evidence to guide MF treatment. There was insufficient evidence for adjunctive or alternative therapies such as acitretin or ECP to treat MF. The authors did not find evidence to refute the recommendation of PUVA as a first-line treatment. Separately, they noted that PUVA combined with IFN-α may lead to a higher CR when compared to IFN-α combined with acitretin. The authors found no evidence to support the addition of bexarotene or intralesional interferon-α (IFN-α) to PUVA when compared to PUVA alone.

#Jochen dermatology plus

From all therapies, the CR ranged from 0% to 83% (median 31%), and the ORR ranged from 0% to 88% (median 47%).ĭata analysis of the five trials assessing the use of psoralen plus UV-A (PUVA) contributed to the key findings of this review, as it is first-line therapy for early-stage MF and is often used as adjunctive treatment in advanced stages. Overall, the evidence indicated that the more aggressive therapies (systemic chemotherapy and combination therapies) resulted in more severe AEs. Common AEs ranged from mild symptoms to severe events. HRQoL was only reported in two studies that could not be analyzed together as it was divided by responder versus nonresponder rather than by treatment group. The ORR was defined as the proportion of patients with a CR or partial response, meaning the regression of measurable disease of at least 50% in the T, N, M, and B categories. A CR was defined as the complete disappearance of all clinical evidence of disease. Secondary outcomes included complete response (CR) and objective response rate (ORR). The authors aimed to assess the efficacy and safety of interventions for MF using two primary outcome measures: health-related quality of life (HRQoL) and adverse events (AEs).

#Jochen dermatology skin

Interventions evaluated in this review included topicals, intralesional therapies, phototherapy, total skin electron beam irradiation, radiotherapy, chemotherapy, extracorporeal photochemotherapy (ECP), biologics, and combination therapies. A 2020 Cochrane review, “Interventions for mycosis fungoides,” provides a comprehensive review of evidence from 20 randomized clinical trials of local and systemic interventions for Alibert-Bazin–type MF (N=1369). The disease is often refractory, with existing treatments providing only a short duration of clinical response. MF remains difficult to treat despite being the most common cutaneous T cell lymphoma. Mycosis fungoides (MF) is a chronic malignant condition characterized by a proliferation of clonal T helper cells in the skin. Asian/Pacific Island Nursing Journal 10 articles.JMIR Bioinformatics and Biotechnology 32 articles.JMIR Biomedical Engineering 68 articles.Journal of Participatory Medicine 78 articles.JMIR Perioperative Medicine 89 articles.JMIR Rehabilitation and Assistive Technologies 201 articles.JMIR Pediatrics and Parenting 279 articles.Interactive Journal of Medical Research 306 articles.JMIR Public Health and Surveillance 1141 articles.Journal of Medical Internet Research 7471 articles.